A simplified total synthesis of the single enantiomers of cocaine and racemic cocaine is outlined. The synthesis employs common laboratory glassware, reagents, and methods which can be performed in most forensic laboratories. The procedure for the isolation and purification of the dextrorotatory.
![Borohydride Borohydride](/uploads/1/2/4/1/124135838/119195737.png)
![Borohydride Reduction 2 Carbomethoxytropinone Borohydride Reduction 2 Carbomethoxytropinone](https://i.stack.imgur.com/s9x7C.png)
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It is not possible to login.Posts 1 - 6 of 6Subject: Findlay's 2=carbomethoxytropinone articlePlease to post( Stranger)07-10-03 23:00No 446280Findlay's 2=carbomethoxytropinone articleThsi article seems to have a glaring error where he uses LiAlH4 to reduce the 2-carbomethoxytropinone to produce the hydroxy group from the ketone carbonyl. Not only would that carbonyl be reduced, but the ester carbonyl would also be reduced yeild a whole host of crap. Why wouldn't he use the obvious NaBH4? The only reason I can think of is the LiAlH4 would preferentially reduce the ketone carbonyl first, this would consume all of the LiAlH4 and there would be none left to react with the ester carbonyl. But this sounds like sledgehammer chemistry, it is possible that the other reason is that NaBH4 forms the incorrect isomer?( Hive Addict)07-13-03 11:54No 446796YesLAH always delivers hydride axially.
And in this case, you are going to want the equtorial alcohol. And, if LAH is used in stoichiometric amounts will reduce ketone only.